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In the adhesive removal test, the rats of PG or SO + PG group showed significantly better performance than those of the control group (Con: 88.1 ± 24.8, PG: 43.6 ± 11, SO + PG: 11.8 ± 7, P <.
The neuronal cell survival and astrocytes expansion were assessed by immunohistofluorescence staining. The cerebral ischemic volume was quantified by Metamorph imaging software after 2-3-5-triphenyltetrazolium (TTC) staining. The rats were subjected to a neurobehavior test including adhesive removal test and rotarod test at 1, 3, 7, 10, and 15 days after MCAO. Animals with MCAO were assigned randomly to one of the following four groups: (1) control (Con) group, (2) SO group (3 mg/kg, intravenously), (3) PG group (200 mg/kg, oral feeding), and (4) SO + PG group. In this study, we assessed the neuroprotective effects that come from a combination therapy of SO and PG in rat models with middle cerebral artery occlusion (MCAO). Recently, many animal studies have suggested that the Panax ginseng (PG) has neuroprotective effects in the ischemic brain. It plays an important role in the prevention of brain damage induced by cerebral ischemia/reperfusion.
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Abstract: Sodium ozagrel (SO) prevents platelet aggregation and vasoconstriction in the cerebral ischemia.
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